US Patents for Sale

The Patents:

“Accelerated Therapeutics” is a term we use to describe a known safe drug that can be repurposed to treat a new indication, and can be expected to provide a superior therapeutic benefit, based on known biochemical pathways and mechanisms of action. We already have US patents for 3 such opportunities, which were issued to and are owned by a single inventor (Mark J. Zamoyski), without any institutional involvement, which would expedite clean assignment of the IP.

Value Proposition:

The value proposition to patients and insurance companies is a superior treatment option, at a fraction of the cost of expensive proprietary drug regimens.

Clinical Development Advantage:

Repurposing can typically be started in a Phase II human proof of efficacy setting, as the drugs have already passed Phase I human safety trials. This results in a short time to market, at low risk and low cost, and is in stark contrast to the very expensive, high risk, and extremely long time to market required for new drug development.

Our Methodology:

Step 1: Our process starts with a Mechanism of Action (MOA) intensive approach of mapping out the molecular pathways underlying the etiology and pathology (pathogenesis) of a disease condition. Repurposing candidates are then identified on mechanistic ability to inhibit either the earliest pathways of the etiology or to inhibit the largest number of pathways in the pathogenesis.

Step 2: Human Clinical data is then reviewed for consistency with the novel pathogenesis and for support for the MOA selected to inhibit the pathogenesis. Academia published studies are avoided when possible because of their high unreliability rate (e.g. Amgen found 47 of the 53 landmark oncology studies published by academia were not reproducible). All studies that are inconsistent with known MOAs and pathways, or do not disclose the MOAs or pathways underlying the claimed empirical results, are largely ignored.

Step 3: The final step is evaluating if the proposed treatment can be expected to provide a therapeutically superior treatment option relative to the current best standard of care.

Three Already Identified Opportunities:

1) Growth Factor Receptor Modulated Cancer Protocols (U.S.: $ 17 Billion Available Market)
- for EGFR overexpressing cancers and estrogen-driven prostate cancer

2) Calcium Ion (Ca++) Homeostasis for Epilepsy and Migraines (U.S.: $ 7.5 Billion Market)
- a pathogenesis inhibiting approach for preventing Seizures and Migraines

3) Targeted Transient Ribosomal Inhibition (U.S.: $ 15 Billion Market)
- a platform drug for several pulmonary and dermal indications

• Accelerated Therapeutics - Science and Market Information (PDF)

Contact Info: If you have interest in any of the above therapeutic areas, please contact Mark Zamoyski,

© 2017 Mark J. Zamoyski